The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and
alternatively serve as a fuel source for peripheral tissues including the brain, heart, and …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Brain-Derived Neurotropic Factor (BDNF) expression is decreased in conditions associated
with cognitive decline as well as metabolic diseases. One potential strategy to improve …

Background Effects of ketone supplements as well as relevant dose-response relationships
and time effects on blood β-hydroxybutyrate (BHB), glucose and insulin are controversial …

Alglucosidase alpha is an orphan drug approved for enzyme replacement therapy (ERT) in
Pompe disease (PD); however, its efficacy is limited in skeletal muscle because of a partial …

Over the last 2 years, we have all been trying to understand the interrelationships of COVID-
19's numerous symptoms, clinical risk factors, and lethality. Autopsy cases of patients with …

Recent advances in emergency medicine and the co-ordinated delivery of trauma care
mean more critically-injured patients now reach the hospital alive and survive life-saving …

Over the last decade, there has been a growing interest in the use of ketone supplements to
improve athletic performance. These ketone supplements transiently elevate the …

While losing and sustaining weight loss has proven challenging, we are optimistic that
application of emerging nutrition science, particularly personalized well-formulated low …