Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Abstract Background: Oxygen (O2) homeostasis is an indispensable requirement of
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …

Photodynamic therapy (PDT) has been known for over a hundred years, but is only now
becoming widely used. Originally developed as a tumor therapy, some of its most successful …

Human embryonic stem (hES) cells are routinely cultured under atmospheric, 20% oxygen
tensions but are derived from embryos which reside in a 3–5% oxygen (hypoxic) …

The α‐chemokine stromal‐derived factor (SDF)‐1 and the G‐protein–coupled seven‐span
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …

The vascular endothelial growth factor A (VEGF-A) is essential during embryonic
development as inactivation of only one allele of its gene results in embryonic lethality. Up …

Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants
plays a pivotal role in organ development and renewal/regeneration of damaged tissues …

Tumor hypoxia presents a major impediment to effective cancer therapy with ionizing
radiation and immune checkpoint inhibitors. Here we report the design of a biomimetic …

The function of the hypoxia-inducible factor-1 (HIF-1), the key transcription factor involved in
cellular adaptation to hypoxia, is restricted to low oxygen tension (pO2). As such, this …

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumor cells. This …