[HTML][HTML] Roles of PI3K/AKT/GSK3 pathway involved in psychiatric illnesses

S Matsuda, Y Ikeda, M Murakami, Y Nakagawa, A Tsuji… - Diseases, 2019 - mdpi.com
Psychiatric illnesses may be qualified to the cellular impairments of the function for survival
or death in neurons, which may consequently appear as abnormalities in the neuroplasticity …

Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights

CE Geisler, MR Hayes - Physiology & behavior, 2023 - Elsevier
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

[HTML][HTML] Habitual daily intake of a sweet and fatty snack modulates reward processing in humans

SE Thanarajah, AG DiFeliceantonio, K Albus… - Cell metabolism, 2023 - cell.com
Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

R Subba, R Sandhir, SP Singh… - European Journal of …, 2021 - Wiley Online Library
Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

[HTML][HTML] Nutrient-mediated perception and signalling in human metabolism: a perspective of nutrigenomics

MK Lal, E Sharma, RK Tiwari, R Devi… - International Journal of …, 2022 - mdpi.com
The interaction between selective nutrients and linked genes involving a specific organ
reveals the genetic make-up of an individual in response to a particular nutrient. The …

[HTML][HTML] High-fat diet-induced weight gain, behavioral deficits, and dopamine changes in young C57BL/6J mice

J Han, P Nepal, A Odelade, FD Freely, DM Belton… - Frontiers in …, 2021 - frontiersin.org
Chronic exposure to a high-fat diet (HFD) may predispose individuals to neuropathologies
and behavioral deficits. The objective of this study was to determine the temporal effects of a …

[HTML][HTML] Food memory circuits regulate eating and energy balance

TR Pardo-Garcia, K Gu, RKR Woerner, M Dus - Current Biology, 2023 - cell.com
In mammals, learning circuits play an essential role in energy balance by creating
associations between sensory cues and the rewarding qualities of food. This process is …

Appetitive traits as targets for weight loss: The role of food cue responsiveness and satiety responsiveness

KN Boutelle, MA Manzano, DM Eichen - Physiology & behavior, 2020 - Elsevier
Individuals with overweight or obesity (OW/OB) are at increased risk for significant physical
and psychological comorbidities. The current treatment for OW/OB is behavioral weight loss …

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

S Li, D Yang, X Zhou, L Chen, L Liu… - CNS Neuroscience …, 2024 - Wiley Online Library
Background The comorbidity between diabetes mellitus and depression was revealed, and
diabetes mellitus increased the prevalence of depressive disorder, which ranked 13th in the …

[HTML][HTML] Brain imaging of taste perception in obesity: a review

C Kure Liu, PV Joseph, DE Feldman, DS Kroll… - Current nutrition …, 2019 - Springer
Abstract Purpose of Review We summarize neuroimaging findings related to processing of
taste (fat, salt, umami, bitter, and sour) in the brain and how they influence hedonic …