Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

The pathogenic mechanisms that underlie Parkinson's disease remain unknown. Here, we
review evidence from both sporadic and genetic forms of Parkinson's disease that implicate …

Animal models of Parkinson's disease (PD) have been widely used in the past four decades
to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …