A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on
different databases about the molecular and environmental origins of disease, into analytic …

Abstract Background Topologically associating domains (TADs) are genomic regions of self-
interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites …

Many valuable resources developed by world-wide research institutions and consortia
describe genomic datasets that are both open and available for secondary research, but …

Advances in high-throughput and digital technologies have required the adoption of big data
for handling complex tasks in life sciences. However, the drift to big data led researchers to …

The integration of genomic metadata is, at the same time, an important, difficult, and well-
recognized challenge. It is important because a wealth of public data repositories is …

With the availability of reliable and low-cost DNA sequencing, human genomics is relevant
to a growing number of end-users, including biologists and clinicians. Typical interactions …

Abstract The Gene Expression Omnibus (GEO) is a public archive containing> 4 million
digital samples from functional genomics experiments collected over almost two decades …

Next Generation Sequencing technologies have produced a substantial increase of publicly
available genomic data and related clinical/biospecimen information. New models and …

Background Population variant analysis is of great importance for gathering insights into the
links between human genotype and phenotype. The 1000 Genomes Project established a …

Background Heterogeneous omics data, increasingly collected through high-throughput
technologies, can contain hidden answers to very important and still unsolved biomedical …