It is of considerable translational importance whether depression is a form or a consequence
of sickness behavior. Sickness behavior is a behavioral complex induced by infections and …

Since its identification in 1989, hepatitis C virus (HCV) has emerged as a worldwide health
problem with roughly 185 million chronic infections, representing individuals at high risk of …

Simeprevir is an NS3/4A protease inhibitor approved for the treatment of hepatitis C
infection, as a component of combination therapy. Simeprevir is metabolized by the …

The present review spans a broad spectrum of topics dealing with alcoholic liver disease
(ALD), including clinical research, translational research, pathogenesis and therapies. A …

Background and aims This study evaluated the clinical and non-clinical determinants of
health-related quality of life (HRQoL) associated with untreated chronic hepatitis C (CHC) in …

Background Depression is the single largest contributor to non-fatal health loss worldwide. A
role of inflammation in major depressive disorder (MDD) was suggested, and we sought to …

In the last two decades, many studies have demonstrated that increased inflammatory
responses occur in patients with affective disorders, which could contribute to the …

Objective To assess the incidence rate and severity of depressive symptoms in different time
points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus …

Background The effectiveness of antiviral therapy with pegylated interferon and ribavirin for
chronic hepatitis C is far from ideal and presents several adverse events. Among such …

Objective Depressive symptoms have been frequently observed in association with immune
activation. We prospectively evaluate depressive symptoms and risk factors for major …