Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Microplastics (MPs) are a ubiquitous pollutant detected not only in marine and freshwater
bodies, but also in tap and bottled water worldwide. While MPs have been extensively …

Remarkable progress has been made in understanding the genetic basis of dilated
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …

Background Clinical interpretation of the large number of rare variants identified by high
throughput sequencing (HTS) technologies is challenging. The aim of this study was to …

A great deal of progress has recently been made in the discovery and understanding of the
genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a …

Substantial progress has been made recently in understanding the genetic basis of
cardiomyopathy. Cardiomyopathies with known genetic cause include hypertrophic (HCM) …

Electrocardiographic measures are indicative of the function of the cardiac conduction
system. To search for sequence variants that modulate heart rate, PR interval and QRS …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) 9
genomic editing has revolutionized the generation of mutant animals by simplifying the …

This review provides an historical and personal perspective on the discovery of genetic
causes for hypertrophic cardiomyopathy (HCM). Extraordinary insights by physicians who …