Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy
AJ Marian, E Braunwald - Circulation research, 2017 - Am Heart Assoc
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
[HTML][HTML] Overview of the muscle cytoskeleton
CA Henderson, CG Gomez, SM Novak… - Comprehensive …, 2017 - ncbi.nlm.nih.gov
Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …
Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences
AF Pedersen, DN Meyer, AMV Petriv, AL Soto… - Environmental …, 2020 - Elsevier
Microplastics (MPs) are a ubiquitous pollutant detected not only in marine and freshwater
bodies, but also in tap and bottled water worldwide. While MPs have been extensively …
bodies, but also in tap and bottled water worldwide. While MPs have been extensively …
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Remarkable progress has been made in understanding the genetic basis of dilated
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …
Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing
Background Clinical interpretation of the large number of rare variants identified by high
throughput sequencing (HTS) technologies is challenging. The aim of this study was to …
throughput sequencing (HTS) technologies is challenging. The aim of this study was to …
Update 2011: clinical and genetic issues in familial dilated cardiomyopathy
RE Hershberger, JD Siegfried - Journal of the American College of …, 2011 - jacc.org
A great deal of progress has recently been made in the discovery and understanding of the
genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a …
genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a …
Genetic evaluation of cardiomyopathy—a Heart Failure Society of America practice guideline
RE Hershberger, J Lindenfeld, L Mestroni… - Journal of cardiac …, 2009 - Elsevier
Substantial progress has been made recently in understanding the genetic basis of
cardiomyopathy. Cardiomyopathies with known genetic cause include hypertrophic (HCM) …
cardiomyopathy. Cardiomyopathies with known genetic cause include hypertrophic (HCM) …
Several common variants modulate heart rate, PR interval and QRS duration
Electrocardiographic measures are indicative of the function of the cardiac conduction
system. To search for sequence variants that modulate heart rate, PR interval and QRS …
system. To search for sequence variants that modulate heart rate, PR interval and QRS …
A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9
KJ Carroll, CA Makarewich… - Proceedings of the …, 2016 - National Acad Sciences
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) 9
genomic editing has revolutionized the generation of mutant animals by simplifying the …
genomic editing has revolutionized the generation of mutant animals by simplifying the …
Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history
CE Seidman, JG Seidman - Circulation research, 2011 - Am Heart Assoc
This review provides an historical and personal perspective on the discovery of genetic
causes for hypertrophic cardiomyopathy (HCM). Extraordinary insights by physicians who …
causes for hypertrophic cardiomyopathy (HCM). Extraordinary insights by physicians who …