One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility.
Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs …

The treatment of advanced ovarian cancer with taxol is hindered by the development of drug
resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol …

Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations
involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human …

PURPOSE: To analyze the available data concerning mechanisms of action of and
mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

The synthesis and structure− activity relationship study of a series of compounds with
heterocycles in place of the cis double bond in combretastatin A-4 (CA-4) are described …

It has been approximately ten years since the Food and Drug Administration (FDA)
approved paclitaxel for the treatment of platinum resistant epithelial ovarian carcinoma …