Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …

Age-related osteoporosis is characterized by the deterioration in bone volume and strength,
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate
of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate …

Abstract Alpha-ketoglutarate (AKG), an endogenous intermediary metabolite in the Krebs
cycle, is a molecule involved in multiple metabolic and cellular pathways. It functions as an …

Abstract l-Glutamine is a nutritionally semi-essential amino acid for proper growth in most
cells and tissues, and plays an important role in the determination and guarding of the …

Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an
essential process influencing the mitochondrial oxidative respiration rate. Recent studies …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …