Antibiotic resistance: one health one world outlook

B Aslam, M Khurshid, MI Arshad… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotic resistance (ABR) is a growing public health concern worldwide, and it is now
regarded as a critical One Health issue. One Health's interconnected domains contribute to …

The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction

DL Turner, RA Mathias - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that can cause severe
disease in immunocompromised individuals, transplant recipients, and to the developing …

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

S Yuan, H Chu, J Huang, X Zhao, ZW Ye, PM Lai… - Science …, 2020 - science.org
Targeting a universal host protein exploited by most viruses would be a game-changing
strategy that offers broad-spectrum solution and rapid pandemic control including the current …

Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster

BI Crawford, MJ Talley, J Russman, J Riddle… - Nature …, 2024 - nature.com
Neural stem and progenitor cell (NSPC) maintenance is essential for ensuring that
organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in …

The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

DL Turner, DV Korneev, JG Purdy, A de Marco… - Elife, 2020 - elifesciences.org
Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause
of congenital birth defects, and poses serious risks for immuno-compromised individuals. To …

[HTML][HTML] Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

J Pollock, AS Low, RE McHugh, A Muwonge… - Clinical microbiology …, 2020 - Elsevier
Background This review follows on from the International Conference on One Health
Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental …

Coatomer protein COPƐ, a novel NS1-interacting protein, promotes the replication of Porcine Parvovirus via attenuation of the production of type I interferon

S Chen, N Chen, B Miao, J Peng, X Zhang, C Chen… - Veterinary …, 2021 - Elsevier
Porcine Parvovirus (PPV) is a pathogen causing porcine reproductive disorders. Non-
structural protein NS1 appears diverse functions acting as a predominant regulator in …

Novel role for escrt-iii component chmp4c in the integrity of the endocytic network utilized for herpes simplex virus envelopment

T Russell, J Samolej, M Hollinshead, GL Smith, J Kite… - MBio, 2021 - Am Soc Microbiol
Enveloped viruses exploit cellular trafficking pathways for their morphogenesis, providing
potential scope for the development of new antiviral therapies. We have previously shown …

CRISPR tackles emerging viral pathogens

EN Kirby, B Shue, PQ Thomas, MR Beard - Viruses, 2021 - mdpi.com
Understanding the dynamic relationship between viral pathogens and cellular host factors is
critical to furthering our knowledge of viral replication, disease mechanisms and …

A novel triple-fluorescent HCMV strain reveals gene expression dynamics and anti-herpesviral drug mechanisms

U Rand, T Kubsch, B Kasmapour… - Frontiers in Cellular and …, 2021 - frontiersin.org
Human Cytomegalovirus (HCMV) infection may result in severe outcomes in
immunocompromised individuals such as AIDS patients, transplant recipients, and …