Following large-scale roll-out of antiretroviral therapy in sub-Saharan Africa, the non-clinical
efficacy of antiretroviral therapy has received little attention. We aimed to systematically …

Early views on the relationship between adherence and resistance postulated a bell-shaped
relationship that balanced selective drug pressure and improved viral suppression along a …

Background Individuals living with HIV/AIDS in sub-Saharan Africa generally take more than
90% of prescribed doses of antiretroviral therapy (ART). This number exceeds the levels of …

Antiretroviral treatment (ART) for HIV is being scaled up rapidly in resource-limited countries.
Treatment options are simplified and standardized, generally with one potent first-line …

Objective: To evaluate adherence, treatment interruptions, and outcomes in patients
purchasing antiretroviral fixed-dose combination (FDC) therapy. Design: Ninety-seven …

Although it is a standard practice in high-income countries, determination of the human
immunodeficiency virus (HIV) load is not recommended in developing countries because of …

Background Antiretroviral therapy (ART) is increasingly available in Africa, but physicians
and clinical services are few. We therefore assessed the effect of a home-based ART …

Background. Access to antiretroviral therapy is rapidly expanding in sub-Saharan Africa.
Identifying the predictors of incomplete adherence, virologic failure, and antiviral drug …

Background: HIV RNA viral load testing is costly and is generally unavailable in resource-
limited settings. We identified predictors of viral failure and documented genotypic mutations …

Objective To characterize the frequency, reasons, risk factors, and consequences of
unstructured anti‐retroviral treatment interruptions. Method Systematic review. Results …