[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Homology modeling in drug discovery: Overview, current applications, and future perspectives

MT Muhammed, E Aki‐Yalcin - Chemical biology & drug design, 2019 - Wiley Online Library
Homology modeling is one of the computational structure prediction methods that are used
to determine protein 3D structure from its amino acid sequence. It is considered to be the …

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

EF Pettersen, TD Goddard, CC Huang… - Protein …, 2021 - Wiley Online Library
UCSF ChimeraX is the next‐generation interactive visualization program from the Resource
for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

J Damas, GM Hughes, KC Keough… - Proceedings of the …, 2020 - National Acad Sciences
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme …

ClinVar: improvements to accessing data

MJ Landrum, S Chitipiralla, GR Brown… - Nucleic acids …, 2020 - academic.oup.com
ClinVar is a freely available, public archive of human genetic variants and interpretations of
their relationships to diseases and other conditions, maintained at the National Institutes of …

In Silico Genotyping of Escherichia coli Isolates for Extraintestinal Virulence Genes by Use of Whole-Genome Sequencing Data

AM Malberg Tetzschner, JR Johnson… - Journal of clinical …, 2020 - Am Soc Microbiol
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause in
humans of urinary tract infection and bacteremia. The previously published web tool …

The BioGRID interaction database: 2019 update

R Oughtred, C Stark, BJ Breitkreutz, J Rust… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

M Bhattacharya, AR Sharma, P Patra… - Journal of medical …, 2020 - Wiley Online Library
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent
outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV …

ClinVar: improving access to variant interpretations and supporting evidence

MJ Landrum, JM Lee, M Benson, GR Brown… - Nucleic acids …, 2018 - academic.oup.com
Abstract ClinVar (https://www. ncbi. nlm. nih. gov/clinvar/) is a freely available, public archive
of human genetic variants and interpretations of their significance to disease, maintained at …

Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

N Koutsodendris, J Blumenfeld, A Agrawal, M Traglia… - Nature aging, 2023 - nature.com
Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …