Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics
R Chabiniok, VY Wang… - Interface …, 2016 - royalsocietypublishing.org
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …
Alya: Multiphysics engineering simulation toward exascale
Alya is a multi-physics simulation code developed at Barcelona Supercomputing Center
(BSC). From its inception Alya code is designed using advanced High Performance …
(BSC). From its inception Alya code is designed using advanced High Performance …
[HTML][HTML] Images as drivers of progress in cardiac computational modelling
Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …
evolving to cover multiple scales and physical mechanisms. They are moving towards …
Fully coupled fluid‐electro‐mechanical model of the human heart for supercomputers
A Santiago, J Aguado‐Sierra… - … journal for numerical …, 2018 - Wiley Online Library
In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …
[HTML][HTML] Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant …
F Levrero-Florencio, F Margara, E Zacur… - Computer methods in …, 2020 - Elsevier
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to
whole organ processes, achieving electrophysiologically-driven mechanical contraction …
whole organ processes, achieving electrophysiologically-driven mechanical contraction …
A comprehensive mathematical model for cardiac perfusion
The aim of this paper is to introduce a new mathematical model that simulates myocardial
blood perfusion that accounts for multiscale and multiphysics features. Our model …
blood perfusion that accounts for multiscale and multiphysics features. Our model …
Estimation of passive and active properties in the human heart using 3D tagged MRI
L Asner, M Hadjicharalambous, R Chabiniok… - … and modeling in …, 2016 - Springer
Advances in medical imaging and image processing are paving the way for personalised
cardiac biomechanical modelling. Models provide the capacity to relate kinematics to …
cardiac biomechanical modelling. Models provide the capacity to relate kinematics to …
Efficient approximation of cardiac mechanics through reduced‐order modeling with deep learning‐based operator approximation
Reducing the computational time required by high‐fidelity, full‐order models (FOMs) for the
solution of problems in cardiac mechanics is crucial to allow the translation of patient …
solution of problems in cardiac mechanics is crucial to allow the translation of patient …
The generalized Hill model: A kinematic approach towards active muscle contraction
Excitation-contraction coupling is the physiological process of converting an electrical
stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential …
stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential …
A predictive model of muscle excitations based on muscle modularity for a large repertoire of human locomotion conditions
Humans can efficiently walk across a large variety of terrains and locomotion conditions with
little or no mental effort. It has been hypothesized that the nervous system simplifies …
little or no mental effort. It has been hypothesized that the nervous system simplifies …