Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics

R Chabiniok, VY Wang… - Interface …, 2016 - royalsocietypublishing.org
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

Alya: Multiphysics engineering simulation toward exascale

M Vázquez, G Houzeaux, S Koric, A Artigues… - Journal of computational …, 2016 - Elsevier
Alya is a multi-physics simulation code developed at Barcelona Supercomputing Center
(BSC). From its inception Alya code is designed using advanced High Performance …

[HTML][HTML] Images as drivers of progress in cardiac computational modelling

P Lamata, R Casero, V Carapella, SA Niederer… - Progress in biophysics …, 2014 - Elsevier
Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …

Fully coupled fluid‐electro‐mechanical model of the human heart for supercomputers

A Santiago, J Aguado‐Sierra… - … journal for numerical …, 2018 - Wiley Online Library
In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …

[HTML][HTML] Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant …

F Levrero-Florencio, F Margara, E Zacur… - Computer methods in …, 2020 - Elsevier
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to
whole organ processes, achieving electrophysiologically-driven mechanical contraction …

A comprehensive mathematical model for cardiac perfusion

A Zingaro, C Vergara, L Dede', F Regazzoni… - Scientific Reports, 2023 - nature.com
The aim of this paper is to introduce a new mathematical model that simulates myocardial
blood perfusion that accounts for multiscale and multiphysics features. Our model …

Estimation of passive and active properties in the human heart using 3D tagged MRI

L Asner, M Hadjicharalambous, R Chabiniok… - … and modeling in …, 2016 - Springer
Advances in medical imaging and image processing are paving the way for personalised
cardiac biomechanical modelling. Models provide the capacity to relate kinematics to …

Efficient approximation of cardiac mechanics through reduced‐order modeling with deep learning‐based operator approximation

L Cicci, S Fresca, A Manzoni… - International Journal for …, 2024 - Wiley Online Library
Reducing the computational time required by high‐fidelity, full‐order models (FOMs) for the
solution of problems in cardiac mechanics is crucial to allow the translation of patient …

The generalized Hill model: A kinematic approach towards active muscle contraction

S Göktepe, A Menzel, E Kuhl - Journal of the Mechanics and Physics of …, 2014 - Elsevier
Excitation-contraction coupling is the physiological process of converting an electrical
stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential …

A predictive model of muscle excitations based on muscle modularity for a large repertoire of human locomotion conditions

J Gonzalez-Vargas, M Sartori, S Dosen… - Frontiers in …, 2015 - frontiersin.org
Humans can efficiently walk across a large variety of terrains and locomotion conditions with
little or no mental effort. It has been hypothesized that the nervous system simplifies …