Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Pathways localizing proteins to their sites of action are essential for eukaryotic cell
organization and function. Although mechanisms of protein targeting to many organelles …

More than 60 years ago, Eugene Kennedy and coworkers elucidated the endoplasmic
reticulum (ER)-based pathways of glycerolipid synthesis, including the synthesis of …

Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors
causing lipid accumulation leading to HCC are not understood. We identify BNIP3 (a …

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

Lipid droplets, as the centre of lipid metabolism, interact with the endoplasmic reticulum,
mitochondria, lysosome, nucleus and other organelles to maintain the body's energy …

Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …