Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

The term “cardiovascular diseases”(CVD) refers to various ailments that affect the heart and
blood vessels, including myocardial ischemia, congenital heart defects, heart failure …

Background: The regenerative capacity of the heart after myocardial infarction is limited. Our
previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin …

Proteasome inhibitors (PIs) are the backbone of combination treatments for patients with
multiple myeloma and AL amyloidosis, while also indicated in Waldenström's …

Proteasomes are the central proteolytic machines that are critical for breaking down most of
the damaged and abnormal proteins in human cells. Although universally applicable drugs …

Nrf1 is a member of the nuclear erythroid 2-like family of transcription factors that regulate
stress-responsive gene expression in animals. Newly synthesized Nrf1 is targeted to the …

Lung diseases are a major global health problem, affecting millions of people worldwide.
Recent research has highlighted the critical role that mitochondrial quality control plays in …

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by
unexplained segmental hypertrophy that is usually most pronounced in the septum. While …

Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue
deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart …

Spatial multi-omic studies have emerged as a promising approach to comprehensively
analyze cells in tissues, enabling the joint analysis of multiple data modalities like …