Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

Peroxisomes transport folded and oligomeric proteins across their membrane. Two cytosolic
import receptors, Pex5p and Pex7p, along with approximately 12 membrane-bound …

The peroxisome represents a ubiquitous single membrane-bound key organelle that
executes various metabolic pathways such as fatty acid degradation by α-and β-oxidation …

Two isoforms of the peroxisomal targeting signal type 1 (PTS1) receptor, termed Pex5pS
and (37-amino-acid-longer) Pex5pL, are expressed in mammals. Pex5pL transports PTS1 …

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal
translocation machinery from the well-characterized translocons of other organelles. How …

The peroxisome biogenesis disorders (PBDs) comprise 12 autosomal recessive
complementation groups (CGs). The multisystem clinical phenotype varies widely in severity …

The peroxisomal disorders represent a group of genetic diseases in humans in which there
is an impairment in one or more peroxisomal functions. The peroxisomal disorders are …

Protein translocation across the peroxisomal membrane requires the concerted action of
numerous peroxins. One central component of this machinery is Pex5p, the cycling receptor …

It is an essential and challenging task to unravel protein–protein interactions in their actual
in vivo context. Native gel systems provide a separation platform allowing the analysis of …