The fragile X syndrome, an X-linked dominant disorder with reduced penetrance, is one of
the most common forms of inherited mental retardation. The cognitive, behavioral, and …

This clinical report describes the clinical genetic evaluation of the child with developmental
delays or mental retardation. The purpose of this report is to describe the optimal clinical …

Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …

The fragile X mutation and fragile X syndrome are associated with hyperarousal,
hyperactivity, aggression, and anxiety. These may be related to strong reactions to auditory …

Epilepsy is reported to occur in 10 to 20% of individuals with fragile X syndrome (FXS). A
frequent seizure/EEG pattern in FXS appears to resemble that of benign focal epilepsy of …

There are no guidelines available for diagnostic studies in patients with mental retardation
(MR) established in an evidence-based manner. Here we report such study, based on …

Sensory hypersensitivity is a common symptom in autism spectrum disorders (ASDs),
including fragile X syndrome (FXS), and frequently leads to tactile defensiveness. In mouse …

Abnormalities in the simplest form of learning, habituation, have been reported in a variety of
neuropsychiatric disorders as etiologically diverse as Autism Spectrum Disorder, Fragile X …

Despite the pronounced neurological deficits associated with mental retardation and autism,
the degree to which neocortical circuit function is altered remains unknown. Here, we study …

Objective. Fragile X syndrome, caused by mutations in a single gene of the X chromosome
(FMR1), is associated with neurobehavioral characteristics including social deficits with …