▪ Abstract Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are
maintained at low levels by regulated production and efficient removal of these thiols. The …

Abnormal concentrations of biothiols such as cysteine, homocysteine and glutathione are
associated with various major diseases. In biological systems, the structural similarity and …

Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals.
The major thiol/disulfide redox couple in human plasma is cysteine (Cys) and its disulfide …

The mammalian liver tightly regulates its free cysteine pool, and intracellular cysteine in rat
liver is maintained between 20 and 100 nmol/g even when sulfur amino acid intakes are …

Highly sensitive and high‐accuracy detection of biomolecular changes is vital for the early
diagnosis and treatment of diverse diseases. Due to their unique advantages and the broad …

Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to
nanoparticles in biological applications. There is abundant literature on the benefits of PEG …

Background and Purpose—We observed recently that elevated plasma cysteine levels are
associated with poor clinical outcome in acute stroke patients. In a rat stroke model, cysteine …

Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction,
and disulphide exchange. The overall thiol pool is the resultant of several individual pools of …

Current evidence suggests that hydrogen sulfide (H2S) plays an important role in brain
functions, probably acting as a neuromodulator as well as an intracellular messenger. In the …

The effects of oxidative stress occur as a result of peroxidative damage of the
macromolecule and membranes of the cells and with the disruption of metabolic activities in …