[HTML][HTML] The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy

ALM Parsons, EMV Bucknor, E Castroflorio, TR Soares… - Antioxidants, 2022 - mdpi.com
One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

Human neuronal maturation comes of age: cellular mechanisms and species differences

JL Wallace, AA Pollen - Nature Reviews Neuroscience, 2024 - nature.com
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

[HTML][HTML] Connectomes across development reveal principles of brain maturation

D Witvliet, B Mulcahy, JK Mitchell, Y Meirovitch… - Nature, 2021 - nature.com
An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …

[HTML][HTML] Neurohybrid memristive CMOS-integrated systems for biosensors and neuroprosthetics

A Mikhaylov, A Pimashkin, Y Pigareva… - Frontiers in …, 2020 - frontiersin.org
Here we provide a perspective concept of neurohybrid memristive chip based on the
combination of living neural networks cultivated in microfluidic/microelectrode system, metal …

Keeping your brain in balance: Homeostatic regulation of network function

W Wen, GG Turrigiano - Annual Review of Neuroscience, 2024 - annualreviews.org
To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

[HTML][HTML] Balance of activity during a critical period tunes a developing network

I Hunter, B Coulson, T Pettini, JJ Davies, J Parkin… - Elife, 2024 - elifesciences.org
Developing neural circuits are influenced by activity and are especially sensitive to changes
in activity during critical periods (CPs) of development. Changes occurring during a CP often …

miR‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity

S Dubes, A Soula, S Benquet, B Tessier… - The EMBO …, 2022 - embopress.org
Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength
to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on …

[HTML][HTML] AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders

K Hori, K Shimaoka, M Hoshino - Cells, 2021 - mdpi.com
Neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASD) and
intellectual disability (ID), are a large group of neuropsychiatric illnesses that occur during …

[HTML][HTML] Activity-dependent plasticity of axo-axonic synapses at the axon initial segment

A Pan-Vazquez, W Wefelmeyer, VG Sabater, G Neves… - Neuron, 2020 - cell.com
The activity-dependent rules that govern the wiring of GABAergic interneurons are not well
understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control …

Homeostatic plasticity in the retina

MJ Fitzpatrick, D Kerschensteiner - Progress in Retinal and Eye Research, 2023 - Elsevier
Vision begins in the retina, whose intricate neural circuits extract salient features of the
environment from the light entering our eyes. Neurodegenerative diseases of the retina (eg …