Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …

The advent of Omics technologies has been key to the molecular subclassification of
urothelial bladder cancer. Several groups have used different strategies to this aim, with …

Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable
disease with greater risks of recurrence and progression relative to their low-intermediate …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA
methylation in gene promoter regions is a major mechanism of gene expression regulation …

Background Aberrant DNA methylation is frequently observed in breast cancer. However,
the relationship between methylation patterns and the heterogeneity of breast cancer has …