High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …

Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …

The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal
transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to …

Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …