The keratins are the typical intermediate filament proteins of epithelia, showing an
outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing …

Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

β-Catenin signaling is required for hair follicle development, but it is unknown whether its
activation is sufficient to globally program embryonic epidermis to hair follicle fate. To …

The mammalian hair follicle (HF) is a complex structure composed of several distinct cell
layers. The HF is an ectodermal appendage that resides in the skin, and unlike other tissues …

Genome-wide studies of African populations have the potential to reveal powerful insights
into the evolution of our species, as these diverse populations have been exposed to …

Terrestrial vertebrates have evolved hard skin appendages, such as scales, claws, feathers,
and hair that play crucial roles in defense, predation, locomotion, and thermal insulation …

We have investigated the expression of 52 of the 54 keratins in beard hair medulla. We
found that not only 12 hair keratins but, unexpectedly, also 12 epithelial keratins are …

Human scalp hairs are comprised of a central cortex enveloped by plate-like cuticle cells.
The elongate cortex cells of mature fibres are composed primarily of macrofibrils-bundles of …

The appearance of hair is one of the main evolutionary innovations in the amniote lineage
leading to mammals. The main components of mammalian hair are cysteine-rich type I and …

The conquest of land was arguably one of the most fundamental ecological transitions in
vertebrates and entailed significant changes in skin structure and appendages to cope with …