Protein aggregation–mechanisms, detection, and control
W Wang, CJ Roberts - International journal of pharmaceutics, 2018 - Elsevier
Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …
development and commercialization of successful protein-based drug products because of …
Science and art of protein formulation development
W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …
expected to grow steadily over the next decade. Development of a commercial protein …
An evaluation of the potential of NMR spectroscopy and computational modelling methods to inform biopharmaceutical formulations
Protein-based therapeutics are considered to be one of the most important classes of
pharmaceuticals on the market. The growing need to prolong stability of high protein …
pharmaceuticals on the market. The growing need to prolong stability of high protein …
[HTML][HTML] Enzyme activity and genetic polymorphisms in patients with type II diabetes mellitus
A Arpaci, S Yalın, H Ecevit… - Advances in Clinical …, 2020 - advances.umw.edu.pl
Background. Diabetes mellitus (DM) has become more and more common and has a high
morbidity and mortality rate worldwide. It is a multifactorial chronic disease affected by both …
morbidity and mortality rate worldwide. It is a multifactorial chronic disease affected by both …
Efficacy, pharmacokinetics, biodistribution and excretion of a novel acylated long-acting insulin analogue INS061 in rats
K Pan, X Shi, K Liu, J Wang, Y Chen - Drug Design, Development …, 2021 - Taylor & Francis
Purpose Long-acting insulin analogues are known to be a major player in the management
of glucose levels in type I diabetic patients. However, highly frequent hypo-and …
of glucose levels in type I diabetic patients. However, highly frequent hypo-and …
[图书][B] The Future of Pharmaceuticals: A Nonlinear Analysis
SK Niazi - 2022 - taylorfrancis.com
Before now, biological systems could only be expressed in terms of linear relationships,
however, as knowledge grows and new techniques of analysis on biological systems is …
however, as knowledge grows and new techniques of analysis on biological systems is …
Insight into human insulin aggregation revisited using NMR derived translational diffusion parameters
J Sitkowski, W Bocian, E Bednarek… - Journal of Biomolecular …, 2018 - Springer
The NMR derived translational diffusion coefficients were performed on unlabeled and
uniformly labeled 13 C, 15 N human insulin in water, both in neat, with zinc ions only, and in …
uniformly labeled 13 C, 15 N human insulin in water, both in neat, with zinc ions only, and in …