Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Emergence of distinct cell types from a common primordium during pituitary development
occurs in response to opposing signaling gradients that induce an overlapping temporal and …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …

Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Mutations in the PROP1 transcription factor gene lead to reduced production of thyrotropin,
GH, prolactin, and gonadotropins as well as to pituitary hypoplasia in adult humans and …

Since human pituitary growth hormone (GH) became available for treatment in 1960,
followed in 1985 by recombinant human GH (rhGH), the diagnosis of GH deficiency (GHD) …

Context: Mutations in transcription factors result in combined pituitary hormone deficiency
(CPHD). Objective: A genetic screening strategy, based on endocrine and neuroradiological …

Introduction: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more
pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and …