[HTML][HTML] IL-1 family cytokines as drivers and inhibitors of trained immunity
LU Teufel, RJW Arts, MG Netea, CA Dinarello… - Cytokine, 2022 - Elsevier
Trained immunity is the long-term memory of innate immune cells, characterised by
increased pro-inflammatory responses towards homo-and heterologous secondary stimuli …
increased pro-inflammatory responses towards homo-and heterologous secondary stimuli …
Structure–function study of a Ca2+-independent metacaspase involved in lateral root emergence
Metacaspases are part of an evolutionarily broad family of multifunctional cysteine
proteases, involved in disease and normal development. As the structure–function …
proteases, involved in disease and normal development. As the structure–function …
Structure‐based discovery of CZL80, a caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility
Background and Purpose Febrile seizures (FS), the most common seizures in childhood and
often accompanied by later epileptogenesis, are not well controlled. Inflammatory processes …
often accompanied by later epileptogenesis, are not well controlled. Inflammatory processes …
[PDF][PDF] Structure-function study of a Ca2+-independent metacaspase involved in lateral root emergence.
Structure–function study of a Ca2+-independent metacaspase involved in lateral root
emergence Page 1 PNAS 2023 Vol. 120 No. 22 e2303480120 https://doi.org/10.1073/pnas.2303480120 …
emergence Page 1 PNAS 2023 Vol. 120 No. 22 e2303480120 https://doi.org/10.1073/pnas.2303480120 …
Structural, computational, docking and biological studies of a triaminopyrimidine caspase-1 inhibitor
In order to more fully characterize the binding properties and activities of a potent, low
nanomolar IC 50 (half maximal inhibitory concentration) inhibitor of caspase-1, CK-1–41, a …
nanomolar IC 50 (half maximal inhibitory concentration) inhibitor of caspase-1, CK-1–41, a …
Huang-Pu-Tong-Qiao Formula Alleviates Hippocampal Neuron Damage by Inhibiting NLRP3 Inflammasome-mediated Pyroptosis in Alzheimer's Disease
N Shao, Z Ding, F Liu, X Zhang, X Wang, S Hu… - Molecular …, 2024 - Springer
Abstract Huang-Pu-Tong-Qiao (HPTQ), a Traditional Chinese Medicine formula, has
achieved remarkable efficacy in clinically treating Alzheimer's disease (AD). Pyroptosis …
achieved remarkable efficacy in clinically treating Alzheimer's disease (AD). Pyroptosis …
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury
H Pang, N Wang, J Chai, X Wang, Y Zhang, Z Bi… - European Journal of …, 2020 - Elsevier
Myocardial infarction (MI) injury is a highly lethal syndrome that has, until recently, suffered
from a lack of clinically efficient targeted therapeutics. The cardiac troponin I interacting …
from a lack of clinically efficient targeted therapeutics. The cardiac troponin I interacting …
Unveiling the Mechanistic Singularities of Caspases: A Computational Analysis of the Reaction Mechanism in Human Caspase-1
Caspases are cysteine proteases in charge of breaking a peptide bond next to an aspartate
residue. Caspases constitute an important family of enzymes involved in cell death and …
residue. Caspases constitute an important family of enzymes involved in cell death and …
Unrevealing the proteolytic activity of RgpB gingipain from computational simulations
Alzheimer's disease represents one of the greatest medical concerns for today's population
and health services. Its multifactorial inherent nature represents a challenge for its treatment …
and health services. Its multifactorial inherent nature represents a challenge for its treatment …
Computational Study of the Inhibition of RgpB Gingipain, a Promising Target for the Treatment of Alzheimer's Disease
Alzheimer's disease represents one of the most ambitious challenges for biomedical
sciences due to the growing number of cases worldwide in the elderly population and the …
sciences due to the growing number of cases worldwide in the elderly population and the …