Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …

The antibody response plays a key role in protection against viral infections. While antiviral
antibodies may reduce the viral burden via several mechanisms, the ability to directly inhibit …

Hepatitis C virus (HCV) infects∼ 2% of the world's population. It is estimated that there are
more than 500,000 new infections annually in Egypt, the country with the highest HCV …

Flaviviruses are small spherical virus particles covered by a dense icosahedral array of
envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and …

Remarkable progress in structural biology has equipped virologists with insight into
structures of viral proteins and virions at increasingly high resolution. Structural information …

We previously developed a panel of neutralizing monoclonal antibodies against Dengue
virus (DENV)-1, of which few exhibited inhibitory activity against all DENV-1 genotypes. This …

Flaviviruses are thought to sample an ensemble of structures at equilibrium. One
consequence of a structurally dynamic virion is the observed time-dependent increases in …

Abstract Dengue virus serotype 2 (DENV2) alone undergoes structural expansion at 37° C
(associated with host entry), despite high sequence and structural homology among the four …

Flaviviruses sample an ensemble of virion conformations resulting from the conformational
flexibility of their structural proteins. To investigate how sequence variation among strains …

Hepatitis C virus (HCV) remains a global problem, despite advances in treatment. The low
cost and high benefit of vaccines have made them the backbone of modern public health …