Immunologically mediated drug reactions have been traditionally classified as unpredictable
based on the fact that they cannot be predicted strictly on the pharmacological action of the …

Rationale: Beryllium continues to have a wide range of industrial applications. Exposure to
beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). Objectives …

The human leukocyte antigen (HLA) genes are the most polymorphic in the human genome
and are critical in regulating specific immunity, hence their historical discovery as “immune …

The Tenth Edition of Hunter's Diseases of Occupations has been fully revised and updated,
presenting all practitioners considering an occupational cause for a patient's condition with …

The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify
both beryllium sensitization and chronic beryllium disease. Approximately 50% of …

T-cell-mediated hypersensitivity to metal cations is common in humans. How the T cell
antigen receptor (TCR) recognizes these cations bound to a major histocompatibility …

Abstract The HLA class II (DRB1 and DQB1) associations with sarcoidosis have been
studied by several groups but often without consistent results. In this paper, we consider the …

Drug hypersensitivity syndromes such as abacavir hypersensitivity and the severe
cutaneous adverse drug reactions have been associated with significant short-and long …

Chronic beryllium disease (CBD) is a fibrotic lung disorder caused by beryllium (Be)
exposure and is characterized by granulomatous inflammation and the accumulation of Be …

Beryllium exposure can cause a granulomatous lung disease in workers who develop a
lymphocyte-mediated sensitization to the metal. Workers in diverse industries are at risk …