Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
An insight of alpha-amylase inhibitors as a valuable tool in the management of type 2 diabetes mellitus
R Bashary, M Vyas, SK Nayak, A Suttee… - Current diabetes …, 2020 - ingentaconnect.com
Background: Among the millions of people around the world, the most prevalent metabolic
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
In vitro α-glucosidase and α-amylase inhibitory potential and molecular docking studies of benzohydrazide based imines and thiazolidine-4-one derivatives
Benzohydrazide based imine derivatives (1c-16c) and thiazolidine-4-one derivatives (1d-
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
[HTML][HTML] Molecular docking of phenolic compounds and screening of antioxidant and antidiabetic potential of Moringa oleifera ethanolic leaves extract from Qassim …
S Chigurupati, A Al-Murikhy, SA Almahmoud… - Saudi Journal of …, 2022 - Elsevier
Introduction Oxidative stress is crucial in diabetic pathophysiology, hence the prerequisite of
ingesting naturally derived antioxidants as a remedial target. This study investigates the …
ingesting naturally derived antioxidants as a remedial target. This study investigates the …
Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials
J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …
New oxadiazole bearing thiosemicarbazide analogues: Synthesis, anti-alzheimer inhibitory potential and their molecular docking study
Synthesized oxadiazole-bearing thiosemicarbazide analogues (1–14) were characterized
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
Synthesis, in vitro α-amylase activity, and molecular docking study of new benzimidazole derivatives
New benzimidazole derivatives were synthesized by reacting substituted phenacyl bromides
with 1 H-benzimidazole-2-thiols. The synthesized compounds were characterized through 1 …
with 1 H-benzimidazole-2-thiols. The synthesized compounds were characterized through 1 …