Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Sample formulations for dissolution dynamic nuclear polarization

T El Daraï, S Jannin - Chemical Physics Reviews, 2021 - pubs.aip.org
Hyperpolarization by dissolution dynamic nuclear polarization (dDNP) can boost magnetic
resonance sensitivity by several orders of magnitude. The method relies on the transfer of …

Triplet dynamic nuclear polarization of guest molecules through induced fit in a flexible metal–organic framework

S Fujiwara, N Matsumoto, K Nishimura… - Angewandte Chemie …, 2022 - Wiley Online Library
Dynamic nuclear polarization utilizing photoexcited triplet electrons (triplet‐DNP) has great
potential for room‐temperature hyperpolarization of nuclear spins. However, the polarization …

Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization

GR Stadler, TF Segawa, M Bütikofer… - Angewandte Chemie …, 2023 - Wiley Online Library
Fragment‐based drug design is a well‐established strategy for rational drug design, with
nuclear magnetic resonance (NMR) on high‐field spectrometers as the method of reference …

[HTML][HTML] Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples

A Capozzi - Scientific Reports, 2022 - nature.com
As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available
hyperpolarization technique for 13C-MRI. Despite the clear path towards personalized …

[HTML][HTML] Fine optimization of a dissolution dynamic nuclear polarization experimental setting for 13C NMR of metabolic samples

A Dey, B Charrier, K Lemaitre, V Ribay… - Magnetic …, 2022 - mr.copernicus.org
NMR-based analysis of metabolite mixtures provides crucial information on biological
systems but mostly relies on 1D 1 H experiments for maximizing sensitivity. However, strong …

Zero-to ultralow-field nuclear magnetic resonance enhanced with dissolution dynamic nuclear polarization

R Picazo-Frutos, Q Stern, JW Blanchard… - Analytical …, 2022 - ACS Publications
Zero-to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance
experiment which does not require strong superconducting magnets. Contrary to …

[HTML][HTML] Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance

J Yeste, M Azagra, MA Ortega, A Portela, G Matajsz… - Lab on a Chip, 2023 - pubs.rsc.org
The sensitivity of NMR may be enhanced by more than four orders of magnitude via
dissolution dynamic nuclear polarization (dDNP), potentially allowing real-time, in situ …

Long-Lived, Transportable Reservoir of Nuclear Polarization Used to Strongly Enhance Solution-State NMR Signals

JM Steiner, Y Quan, TR Eichhorn… - The Journal of …, 2023 - ACS Publications
There is a fundamental issue with the use of dynamic nuclear polarization (DNP) to enhance
nuclear spin polarization: the same polarizing agent (PA) needed for DNP is also …

Rapid and Simple 13C-Hyperpolarization by 1H Dissolution Dynamic Nuclear Polarization Followed by an Inline Magnetic Field Inversion

Q Stern, Q Reynard-Feytis, SJ Elliott… - Journal of the …, 2023 - ACS Publications
Dissolution dynamic nuclear polarization (dDNP) is a method of choice for preparing
hyperpolarized 13C metabolites such as 1-13C-pyruvate used for in vivo applications …