Diabetes often leads to a number of complications involving brain function, including
cognitive decline and depression. In addition, depression is a risk factor for developing …

It is now well established that the mammalian brain has the capacity to produce new
neurons into adulthood. One such region that provides the proper milieu to sustain …

Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …

Cognitive dysfunction and dementia have recently been proven to be common (and
underrecognized) complications of diabetes mellitus (DM). In fact, several studies have …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Diabetic cognitive impairment (DCI) is a complex complication of diabetes in the central
nervous system, and its pathological mechanism is still being explored. Astrocytes are …

Unlike responses to acute stressful events that are protective and adaptive in nature, chronic
stress elicits neurochemical, neuroanatomical and cellular changes that may have …

The escalating obesity/diabetes epidemic is an important health-care issue that has crucial
socio-economic ramifications. The complications of diabetes/obesity phenotypes extend to …

These last two decades have seen an explosion of clinical and epidemiological research,
and basic research devoted to envisage the influence of gender and hormonal fluctuations …