Memantine (3, 5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-
D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe …

Proteins are major drug targets, and drug–target interaction identification and analysis are
important factors for drug discovery. Atomic force microscopy (AFM) is a powerful tool …

Amyloid aggregation of protein is linked to many neurodegenerative diseases. Identification
of small molecules capable of targeting amyloidogenic proteins has gained significant …

A series of tacrine–benzothiazole hybrids incorporate inhibitors of acetylcholinesterase
(AChE), amyloid β (Aβ) aggregation and mitochondrial enzyme ABAD, whose interaction …

Amyloid protein aggregation is responsible for a variety of neurodegenerative diseases, and
antiamyloidogenic small molecules are identified for inhibiting such protein aggregation at …

Amyloidoses represent a group of pathological conditions characterized by amyloid fibrils
accumulating in the form of deposits in intra-or extracellular space, leading to tissue …

Neurodegenerative diseases are a group of debilitating maladies involving protein
aggregation. To this day, all advances in neurodegenerative disease therapeutics have …

Fragment-based drug discovery, as a complementary method to traditional screening, has a
broad momentum of development in academia, as well as large pharmaceutical companies …

Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading around the …

Kidney-associated human lysozyme amyloidosis leads to renal impairments; thus, patients
are often prescribed furosemide. Based on this fact, the effect of furosemide on induced …