Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …

Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …

Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …

Mutations in the LRRK2 gene represent the most common genetic cause of late onset
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …