[HTML][HTML] RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Abstract N 6-methyladenosine (m6A) methylation can be deposited on chromatin-associated
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …
[HTML][HTML] RUNX proteins as epigenetic modulators in cancer
RUNX proteins are highly conserved in metazoans and perform critical functions during
development. Dysregulation of RUNX proteins through various molecular mechanisms …
development. Dysregulation of RUNX proteins through various molecular mechanisms …
[HTML][HTML] New insights into TRP ion channels in stem cells
J Guo, C Shan, J Xu, M Li, J Zhao… - International Journal of …, 2022 - mdpi.com
Transient receptor potential (TRP) ion channels are cationic permeable proteins located on
the plasma membrane. TRPs are cellular sensors for perceiving diverse physical and/or …
the plasma membrane. TRPs are cellular sensors for perceiving diverse physical and/or …
[HTML][HTML] Intermittent exposure to a 16 Hz extremely low frequency pulsed electromagnetic field promotes osteogenesis in vitro through activating Piezo 1-induced …
Y Chen, BJ Braun, MM Menger, M Ronniger… - Journal of Functional …, 2023 - mdpi.com
Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is
supposed to simulate local EMF generated during mechanical stimulation of bone and may …
supposed to simulate local EMF generated during mechanical stimulation of bone and may …
[HTML][HTML] Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
S Choi, JA Kim, H Li, SE Jo, H Lee, TH Kim… - Biomedicine & …, 2021 - Elsevier
Small-and intermediate-conductance Ca 2+-activated K+ channels, K Ca 2.3 and K Ca 3.1,
are involved in cellular signaling processes associated with inflammation and fibrosis. K Ca …
are involved in cellular signaling processes associated with inflammation and fibrosis. K Ca …
[HTML][HTML] Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia
L Zhou, C Ni, R Liao, X Tang, T Yi, M Ran, M Huang… - Elife, 2024 - elifesciences.org
Thrombocytopenia caused by long-term radiotherapy and chemotherapy exists in cancer
treatment. Previous research demonstrates that 5-Hydroxtrayptamine (5-HT) and its …
treatment. Previous research demonstrates that 5-Hydroxtrayptamine (5-HT) and its …
[HTML][HTML] ERK phosphorylation regulates the Aml1/Runx1 splice variants and the TRP channels expression during the differentiation of glioma stem cell lines
The identification of cancer stem cells in brain tumors paved the way for new therapeutic
approaches. Recently, a role for the transcriptional factor Runx1/Aml1 and the downstream …
approaches. Recently, a role for the transcriptional factor Runx1/Aml1 and the downstream …
Comparative hematopoiesis and signal transduction in model organisms
Hematopoiesis is a continuous phenomenon involving the formation of hematopoietic stem
cells (HSCs) giving rise to diverse functional blood cells. This developmental process of …
cells (HSCs) giving rise to diverse functional blood cells. This developmental process of …
[HTML][HTML] Regulation of ion channel function in human-induced pluripotent stem cell-derived cardiomyocytes by cancer cell secretion through DNA methylation
R Zhong, F Zhang, Z Yang, Y Li, Q Xu, H Lan… - Frontiers in …, 2022 - frontiersin.org
Background Cardiac dysfunction including arrhythmias appear frequently in patients with
cancers, which are expected to be caused mainly by cardiotoxic effects of chemotherapy …
cancers, which are expected to be caused mainly by cardiotoxic effects of chemotherapy …
[HTML][HTML] RUNX1 overexpression triggers TGF-β signaling to upregulate p15 and thereby blocks early hematopoiesis by inducing cell cycle arrest
W Sun, D Yi, L Zhu, J Zeng, Y Liu, J Chang, J Teng… - Stem Cell Research, 2022 - Elsevier
Abstract p15 INK4b (cyclin-dependent kinase inhibitor 2B, CDKN2B, p15), a cyclin-
dependent kinase inhibitor (CKI) belonging to the INK4 family, plays an important role in …
dependent kinase inhibitor (CKI) belonging to the INK4 family, plays an important role in …