New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)
D Rosenbaum, P Saftig - The FEBS journal, 2024 - Wiley Online Library
The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
Z Ye, W Chen, G Li, J Huang, J Lei - Cancer and Metastasis Reviews, 2024 - Springer
Extracellular vesicles (EVs) are small lipid bilayer–enclosed vesicles that mediate vital
cellular communication by transferring cargo between cells. Among these, tissue-derived …
cellular communication by transferring cargo between cells. Among these, tissue-derived …
Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
K Li, W Xue, Z Lu, S Wang, J Zheng, K Lu, M Li… - Journal of Experimental …, 2024 - Springer
Background Hematological metastasis has been recognized as a crucial factor contributing
to the high rates of metastasis and mortality observed in colorectal cancer (CRC). Notably …
to the high rates of metastasis and mortality observed in colorectal cancer (CRC). Notably …
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Q Shi, C Xue, Y Zeng, X Yuan, Q Chu, S Jiang… - … and Targeted Therapy, 2024 - nature.com
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation
X Li, X Meng, H Fan, Y Wang, Y Jia, J Jiao… - Archives of …, 2024 - Springer
Skin cutaneous melanoma (SKCM) is the skin malignancy with the highest mortality rate,
and its morbidity rate is on the rise worldwide. Smoking is an independent marker of poor …
and its morbidity rate is on the rise worldwide. Smoking is an independent marker of poor …