Exploiting chemical protein synthesis to study the role of tyrosine sulfation on anticoagulants from hematophagous organisms
JWC Maxwell, PME Hawkins, EE Watson… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Tyrosine sulfation is a post-translational modification (PTM) that modulates
function by mediating key protein–protein interactions. One of the early proteins shown to …
function by mediating key protein–protein interactions. One of the early proteins shown to …
Uncommon posttranslational modifications in proteomics: ADP‐ribosylation, tyrosine nitration, and tyrosine sulfation
A Bashyal, JS Brodbelt - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Posttranslational modifications (PTMs) are covalent modifications of proteins that modulate
the structure and functions of proteins and regulate biological processes. The development …
the structure and functions of proteins and regulate biological processes. The development …
Development of supramolecular anticoagulants with on-demand reversibility
Drugs are administered at a dosing schedule set by their therapeutic index, and termination
of action is achieved by clearance and metabolism of the drug. In some cases, such as …
of action is achieved by clearance and metabolism of the drug. In some cases, such as …
Exploring a Hirudin variant from nonhematophagous leeches: Unraveling full-length sequence, alternative splicing, function, and potential as a novel anticoagulant …
X Yi, J Liu, E Zang, Y Tian, J Liu, L Shi - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Leeches exhibit robust anticoagulant activity, making them
useful for treating cardiovascular diseases in traditional Chinese medicine. Whitmania pigra …
useful for treating cardiovascular diseases in traditional Chinese medicine. Whitmania pigra …
Characterization of protein post-translational modifications using 193 nm ultraviolet photodissociation mass spectrometry
A Bashyal - 2023 - repositories.lib.utexas.edu
Protein characterization remains the highest-impact application and one of the critical
challenges for mass spectrometry. The dissertation begins with a fundamental investigation …
challenges for mass spectrometry. The dissertation begins with a fundamental investigation …