Bilayered phospholipid membranes are vital to the organization of the living cell. Based on
fundamental principles of polarity, membranes create borders allowing defined spaces to be …

Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal
turnover of a wide variety of substrates including proteins, aggregates, organelles, and …

Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes
like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via …

Endosomal protein sorting controls the localization of many physiologically important
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …

Genetic variations in the autophagic pathway influence genetic predispositions to Crohn
disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic …

Abstract The Rab GAP protein TBC 1D5 controls cellular endomembrane trafficking
processes and binds the retromer subunit VPS 29 and the ubiquitin‐like protein ATG 8 (LC …

Autophagy is a degradation system for intracellular components. One of the roles of
autophagy is the prompt removal of damaged organelles. Another unique role is to supply …

The hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous
group of disorders characterized by progressive lower limb spasticity. Mutations in subunits …

Autophagy is an intracellular degradation system that, as a basic mechanism it delivers
cytoplasmic components to the lysosomes in order to maintain adequate energy levels and …

Autophagy degrades pathogens, altered organelles and protein aggregates, and is
characterized by the sequestration of cytoplasmic cargos within double-membrane-limited …