Hepatorenal syndrome: pathophysiology, diagnosis, and management

DA Simonetto, P Gines, PS Kamath - bmj, 2020 - bmj.com
Hepatorenal syndrome (HRS), the extreme manifestation of renal impairment in patients with
cirrhosis, is characterized by reduction in renal blood flow and glomerular filtration rate …

News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the International Club of Ascites (ICA) consensus document

P Angeli, G Garcia-Tsao, MK Nadim, CR Parikh - Journal of hepatology, 2019 - Elsevier
Renal dysfunction is a common, life-threatening complication occurring in patients with liver
disease. Hepatorenal syndrome (HRS) has been defined as a purely “functional” type of …

Terlipressin plus albumin for the treatment of type 1 hepatorenal syndrome

F Wong, SC Pappas, MP Curry… - … England Journal of …, 2021 - Mass Medical Soc
Background The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-
1) in many parts of the world and is part of the clinical practice guidelines in Europe …

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

[HTML][HTML] Liver—guardian, modifier and target of sepsis

P Strnad, F Tacke, A Koch, C Trautwein - … reviews Gastroenterology & …, 2017 - nature.com
Sepsis and septic shock are characterized by life-threatening organ dysfunction caused by a
dysregulated host response to infection. The liver has a central role during sepsis, and is …

Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites

P Angeli, P Ginès, F Wong, M Bernardi, TD Boyer… - Gut, 2015 - gut.bmj.com
Acute renal failure (ARF) is a common complication in patients with decompensated
cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in …

[HTML][HTML] Human serum albumin, systemic inflammation, and cirrhosis

V Arroyo, R García-Martinez, X Salvatella - Journal of hepatology, 2014 - Elsevier
Human serum albumin (HSA) is one of the most frequent treatments in patients with
decompensated cirrhosis. Prevention of paracentesis-induced circulatory dysfunction …

Terlipressin plus albumin is more effective than albumin alone in improving renal function in patients with cirrhosis and hepatorenal syndrome type 1

TD Boyer, AJ Sanyal, F Wong, RT Frederick, JR Lake… - Gastroenterology, 2016 - Elsevier
Background & Aims Hepatorenal syndrome type 1 (HRS-1) in patients with cirrhosis and
ascites is a functional, potentially reversible, form of acute kidney injury characterized by …

AGA clinical practice update on the evaluation and management of acute kidney injury in patients with cirrhosis: expert review

SL Flamm, F Wong, J Ahn, PS Kamath - Clinical Gastroenterology and …, 2022 - Elsevier
Description The purpose of this American Gastroenterological Association (AGA) Institute
Clinical Practice Update is to review the available published evidence and expert advice …

[PDF][PDF] Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: a randomized trial

M Cavallin, PS Kamath, M Merli, S Fasolato… - …, 2015 - Wiley Online Library
Hepatorenal syndrome (HRS), a serious complication of cirrhosis, is associated with high
mortality without treatment. Terlipressin with albumin is effective in the reversal of HRS …