Conditioned media from cell lines: A complementary model to clinical specimens for the discovery of disease‐specific biomarkers
P Dowling, M Clynes - Proteomics, 2011 - Wiley Online Library
In the strictest sense, the cell secretome (conditioned media) refers to the collection of
proteins that contain a signal peptide and are processed via the endoplasmic reticulum and …
proteins that contain a signal peptide and are processed via the endoplasmic reticulum and …
Angiocrine regulation of epithelial barrier integrity in inflammatory bowel disease
Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the
disease is rising. A major step in disease development is the breakdown of the epithelial cell …
disease is rising. A major step in disease development is the breakdown of the epithelial cell …
The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication
GR Gariano, V Dell'Oste, M Bronzini, D Gatti… - PLoS …, 2012 - journals.plos.org
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular
DNA, modulates various cell functions, however, its role in regulating virus growth remains …
DNA, modulates various cell functions, however, its role in regulating virus growth remains …
Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system
FB Gilbert, P Cunha, K Jensen, EJ Glass, G Foucras… - Veterinary …, 2013 - Springer
Mastitis caused by Escherichia coli and Staphylococcus aureus is a major pathology of dairy
cows. To better understand the differential response of the mammary gland to these two …
cows. To better understand the differential response of the mammary gland to these two …
Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing …
V Dell'Oste, D Gatti, F Gugliesi, M De Andrea… - Journal of …, 2014 - Am Soc Microbiol
Intrinsic immune mechanisms mediated by constitutively expressed proteins termed
“restriction factors” provide frontline antiviral defense. We recently demonstrated that the …
“restriction factors” provide frontline antiviral defense. We recently demonstrated that the …
The nuclear DNA sensor IFI16 acts as a restriction factor for human papillomavirus replication through epigenetic modifications of the viral promoters
I Lo Cigno, M De Andrea, C Borgogna… - Journal of …, 2015 - Am Soc Microbiol
The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA,
was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) …
was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) …
Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts
X Duan, L Ponomareva, S Veeranki… - Molecular Cancer …, 2011 - AACR
The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic
double-stranded DNA (dsDNA). On sensing dsDNA, the IFI16 protein induces the …
double-stranded DNA (dsDNA). On sensing dsDNA, the IFI16 protein induces the …
Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA
S Chiliveru, SH Rahbek, SK Jensen… - The Journal of …, 2014 - journals.aai.org
Keratinocytes are involved in protecting the body from infections and environmental
challenges, but also in inflammatory conditions like psoriasis. DNA has emerged as a potent …
challenges, but also in inflammatory conditions like psoriasis. DNA has emerged as a potent …
Regulatory interaction between the cellular restriction factor IFI16 and viral pp65 (pUL83) modulates viral gene expression and IFI16 protein stability
M Biolatti, V Dell'Oste, S Pautasso, J Von Einem… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT A key player in the intrinsic resistance against human cytomegalovirus (HCMV)
is the interferon-γ-inducible protein 16 (IFI16), which behaves as a viral DNA sensor in the …
is the interferon-γ-inducible protein 16 (IFI16), which behaves as a viral DNA sensor in the …
IFI16: at the interphase between innate DNA sensing and genome regulation
MR Jakobsen, SR Paludan - Cytokine & growth factor reviews, 2014 - Elsevier
DNA carries the genetic code, and is also a potent stimulator of innate immune responses.
IFI16 is a member of the family of PYHIN proteins and is composed of a PYRIN domain …
IFI16 is a member of the family of PYHIN proteins and is composed of a PYRIN domain …