With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …

The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …

Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and
Cryptococcus neoformans species complexes. After more than 15 years of molecular …

In recent decades, fungal infections have emerged as an important health problem
associated with more people who present deficiencies in the immune system, such as HIV or …

Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

Guanine nucleotides are required for growth and viability of cells due to their structural role
in DNA and RNA, and their regulatory roles in translation, signal transduction, and cell …

The incidence of fungal infections has increased continuously in recent years, and drug
resistance, especially resistance to fluconazole (FLC), has emerged. To overcome this …

Ascospores generated during sexual reproduction are the primary inoculum for the wheat
scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in …

Purines play an integral role in cellular processes such as energy metabolism, cell signaling
and encoding the genetic makeup of all living organisms—ensuring that the purine …

Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei
(Tb). Inosine-5'-monophosphate dehydrogenase (IMPDH) has been proposed as a potential …