Evolution and diversity of HIV-1 in Africa–a review

MA Papathanasopoulos, GM Hunt, CT Tiemessen - Virus genes, 2003 - Springer
The HIV/AIDS pandemic represents a major development crisis for the African continent,
which is the worst affected region in the world. Currently, almost 30 of the 42 million people …

The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with …

V Novitsky, CW Wester, V DeGruttola… - AIDS research and …, 2007 - liebertpub.com
HIV-1C has become the dominant HIV-1 subtype in the global AIDS epidemic. Historically,
the evolution of drug-resistant mutations was characterized primarily among antiretroviral …

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections

CM Rousseau, GH Learn, T Bhattacharya… - Journal of …, 2007 - Am Soc Microbiol
Recombinant human immunodeficiency virus type 1 (HIV-1) strains containing sequences
from different viral genetic subtypes (intersubtype) and different lineages from within the …

Trends and measurement of HIV prevalence in northern Malawi

AC Crampin, JR Glynn, BMM Ngwira, FD Mwaungulu… - Aids, 2003 - journals.lww.com
Background: Most data on HIV prevalence in Malawi come from antenatal clinic (ANC)
surveillance and are, therefore, subject to bias. Objectives: HIV prevalence and risk factors …

Comparative population dynamics of HIV-1 subtypes B and C: subtype-specific differences in patterns of epidemic growth

PR Walker, OG Pybus, A Rambaut… - Infection, Genetics and …, 2005 - Elsevier
The human immunodeficiency virus (HIV) pandemic continues to grow at an alarming rate,
with a further 5 million new infections in 2003. Some 3.5 million of these were in sub …

Analysis of the history and spread of HIV-1 in Uganda using phylodynamics

G Yebra, M Ragonnet-Cronin… - Journal of General …, 2015 - microbiologyresearch.org
HIV prevalence has decreased in Uganda since the 1990s, but remains substantial within
high-risk groups. Here, we reconstruct the history and spread of HIV subtypes A1 and D in …

Cross-reactivity of anti–HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1–positive individuals from 4 continents

PM Coplan, SB Gupta, SA Dubey… - The Journal of …, 2005 - academic.oup.com
Background The genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the
question of whether vaccines that include a component to elicit antiviral T cell immunity …

Emergence of X4 usage among HIV-1 subtype C: evidence for an evolving epidemic in South Africa

BJ Connell, K Michler, A Capovilla, WDF Venter… - Aids, 2008 - journals.lww.com
This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African
AIDS patients. We found the highest percentage of CXCR4 usage among primary isolates …

Evolution and molecular epidemiology of subtype C HIV-1 in Zimbabwe

SC Dalai, T de Oliveira, GW Harkins, SG Kassaye… - Aids, 2009 - journals.lww.com
Objective: To investigate the origins and evolutionary history of subtype C HIV-1 in
Zimbabwe in a context of regional conflict and migration. Design: HIV-1C pol sequence …

Epidemiologic and molecular characterization of human immunodeficiency virus type 1 in southern Brazil

EAJM Soares, RP Santos, JA Pellegrini… - JAIDS Journal of …, 2003 - journals.lww.com
HIV subtype C is the most prevalent subtype in the world. Despite its recent expansion in
Brazil, HIV-1C already prevails in the southernmost state of Brazil, Rio Grande do Sul. This …