Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Exercise confers numerous salutary effects that extend beyond individual organ systems to
provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular …

Abstract ChEMBL (https://www. ebi. ac. uk/chembl/) is a manually curated, high-quality, large-
scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like …

Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide
association studies that elucidate genetic etiology of complex traits. However, individuals …

Precision medicine provides patients with access to personally tailored treatments based on
individual-level data. However, developing personalized therapies requires analyses with …

Heart failure with preserved ejection fraction (HFpEF) is a major, worldwide health-care
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …

Background Altered metabolism plays a role in the pathophysiology of cardiac diseases,
such as atrial fibrillation (AF) and heart failure (HF). We aimed to identify novel plasma …

Given expanding studies in epidemiology and disease-oriented human studies offering
hundreds of associations between the human" ome" and disease, prioritizing molecules …

The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …

Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with scarce
therapeutic alternatives, which imposes a significant economic burden on society. The …