Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Peptide natural products are important lead structures for human drugs and many
nonribosomal peptides possess antibiotic activity. This makes them interesting targets for …

Backbone N-methylation and macrocyclization improve the pharmacological properties of
peptides by enhancing their proteolytic stability, membrane permeability and target …

Borosins are ribosomally synthesized and post-translationally modified peptides (RiPPs)
with α-N-methylations installed on the peptide backbone that impart unique properties like …

Backbone N-methylation is one of the prominent peptide modifications that can greatly
enhance the pharmacological properties of a peptide. Naturally occurring backbone N …

The methylation of peptide backbone amides is a hallmark of bioactive natural products, and
it also greatly modifies the pharmacology of synthetic peptides. Usually, bioactive N …

Multiple backbone N‐methylation and macrocyclization improve the proteolytic stability and
oral availability of therapeutic peptides. Chemical synthesis of such peptides is challenging …

N-methylation of peptide backbones has often been utilized as a strategy toward the
development of peptidic drugs. However, difficulties in the chemical synthesis, high cost of …

Fungal ribosomally synthesized and post-translationally modified peptides (RiPPs) are a
vital class of natural products known for their biological activities including anticancer …

Highlights•Methylated amides have application in medicine.•Chemical methylation of
peptides is challenging.•Enzymes which methylated amides have been characterised.•The …