Fatigue as a symptom or comorbidity of neurological diseases

IK Penner, F Paul - Nature Reviews Neurology, 2017 - nature.com
Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in
the context of various neurological diseases. The high prevalence of fatigue as either a …

A narrative review of cancer-related fatigue (CRF) and its possible pathogenesis

S Yang, S Chu, Y Gao, Q Ai, Y Liu, X Li, N Chen - Cells, 2019 - mdpi.com
Many cancer patients suffer from severe fatigue when treated with chemotherapy or
radiotherapy; however, the etiology and pathogenesis of this kind of fatigue remains …

Deep gray matter volume loss drives disability worsening in multiple sclerosis

A Eshaghi, F Prados, WJ Brownlee… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Fatigue in multiple sclerosis—a brief review

I Induruwa, CS Constantinescu, B Gran - Journal of the neurological …, 2012 - Elsevier
Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is
believed to be distinctly different from fatigue seen in other chronic conditions. It can affect a …

Fatigue in multiple sclerosis–insights into evaluation and management

SS Ayache, MA Chalah - Neurophysiologie Clinique/Clinical …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

MR imaging of multiple sclerosis

M Filippi, MA Rocca - Radiology, 2011 - pubs.rsna.org
Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite
detail, conventional magnetic resonance (MR) imaging has become an established tool in …

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

G Morris, M Berk, K Walder, M Maes - BMC medicine, 2015 - Springer
Background The genesis of severe fatigue and disability in people following acute pathogen
invasion involves the activation of Toll-like receptors followed by the upregulation of …

Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue

C Finke, J Schlichting, S Papazoglou… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Background: Fatigue is one of the most frequent and disabling symptoms in multiple
sclerosis, but its pathophysiological mechanisms are poorly understood. It is in particular …

Multiple sclerosis and fatigue: a review on the contribution of inflammation and immune-mediated neurodegeneration

R Patejdl, IK Penner, TK Noack, UK Zettl - Autoimmunity reviews, 2016 - Elsevier
Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS)
and the leading cause of non-traumatic disability among young and middle-aged adults in …

The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases

G Morris, M Berk, P Galecki, K Walder, M Maes - Molecular neurobiology, 2016 - Springer
Many patients with systemic immune-inflammatory and neuro-inflammatory disorders,
including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's disease …