Sickle cell disease (SCD) is characterized by deoxygenation–induced polymerization of
hemoglobin in red blood cells, leading to hemolytic anemia, vaso–occlusion, and the …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Background: Anemia is a wide-spread public health problem characterized by a decrease in
hemoglobin concentration and/or red blood cell volume below an established cut-off value …

Background Sickle cell disease (SCD) is an inherited blood disorder that predominantly
affects individuals in sub-Saharan Africa. However, research that elucidates links between …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Pulmonary hypertension (PH) is a devastating, progressive disease with increasingly
debilitating symptoms and usually shortened overall life expectancy. This article reviews the …

Introduction: Sickle cell disease (SCD) is an inherited blood disorder characterized by
clinical heterogeneity that may be influenced by environmental factors, ethnicity, race, social …

Background Despite the huge burden of sickle cell disease (SCD) among Nigerian children,
the burden and outcome of respiratory illnesses remain undocumented. Thus, we aimed to …

Pulmonary hypertension (PH) is a complex puzzle in Africa, especially among children who
present with a cocktail of issues including recurrent pulmonary infections, unoperated …

Background Pulmonary artery hypertension (PAH) is a known complication of patients with
sickle cell disease (SCD). The prevalence of PAH has been reported to be high in children …