Gene therapy offers great opportunities for the treatment of severe diseases including
cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become …

Biotherapies have revolutionized the treatment of RA. However, much work is needed to
understand all the mechanisms of these biotherapies, and alternatives are needed to …

Purpose Short linear peptides have a high potential for delivering various drugs with
therapeutic potential, including nucleic acids. Recently, we have shown that the cationic …

In the RNA interference process, the catalytic degradation of an endogenous mRNA results
from the Watson-Crick complementary recognition by either a small silencing synthetic …

We recently reported a cationic lipid-based vector of siRNA, termed siRNA lipoplex that was
very efficient in specific gene silencing, both in cell culture and in mouse disease models. To …

SiRNA is the trigger of RNA interference, a mechanism discovered in the late 1990s. To
release the therapeutic potential of this versatile but large and fragile molecule, excipients …

Effective vaccine formulations consist of several components: an antigen carrier, the antigen,
a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a …

Cells from the mononuclear phagocyte system (MPS) act as systemic and local amplifiers
that contribute to the progression of chronic inflammatory disorders. Transforming growth …

By Michael addition polymerization of N, N'-cystaminebisacrylamide (CBA) with variable
ratios of 4-amino-1-butanol (ABOL) and ethylene diamine (EDA) or triethylenetetramine …

Microfluidization has been investigated as a new, scalable, and basic component saving
method to produce cationic lipid nanoparticles, in particular for the delivery of short …