[HTML][HTML] Genetic aberrations in macroautophagy genes leading to diseases
N van Beek, DJ Klionsky, F Reggiori - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
The catabolic process of macroautophagy, through the rapid degradation of unwanted
cellular components, is involved in a multitude of cellular and organismal functions that are …
cellular components, is involved in a multitude of cellular and organismal functions that are …
A current view of molecular dissection in autophagy machinery
MAA Al-Bari - Journal of physiology and biochemistry, 2020 - Springer
Macroautophagy (hereafter called autophagy) is a highly conserved lysosomal pathway for
catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential …
catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential …
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian
defect in humans characterized by the premature depletion of ovarian follicles before the …
defect in humans characterized by the premature depletion of ovarian follicles before the …
PI4K2A deficiency causes innate error in intracellular trafficking with developmental and epileptic‐dyskinetic encephalopathy
HS Dafsari, JG Pemberton, EA Ferrer… - Annals of Clinical …, 2022 - Wiley Online Library
Objective Intracellular signaling networks rely on proper membrane organization to control
an array of cellular processes such as metabolism, proliferation, apoptosis, and …
an array of cellular processes such as metabolism, proliferation, apoptosis, and …
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention
C Lanzillotta, I Zuliani, A Tramutola, E Barone… - Progress in …, 2021 - Elsevier
A major challenge in neurobiology is the identification of the mechanisms by which protein
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …
[HTML][HTML] Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation
J Gu, K Li, H Lin, Y Wang, Y Zhou, D Chen, X Gu… - Ecotoxicology and …, 2023 - Elsevier
Environmental and occupational exposure to cadmium (Cd) poses a serious threat to human
health. Recent studies indicate that Cd perturbs the immune system and increases the risk of …
health. Recent studies indicate that Cd perturbs the immune system and increases the risk of …
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome
S Pagnotta, A Tramutola, E Barone… - Free Radical Biology …, 2022 - Elsevier
The cells possess several mechanisms to counteract the over-production of reactive oxygen
species (ROS) and reactive nitrogen species (RNS), including enzymes such as superoxide …
species (ROS) and reactive nitrogen species (RNS), including enzymes such as superoxide …
New insights into the genetic predisposition of brucellosis and its effect on the gut and vaginal microbiota in goats
AM Sallam, I Abou-Souliman, H Reyer, K Wimmers… - Scientific Reports, 2023 - nature.com
Goats contribute significantly to the global food security and industry. They constitute a main
supplier of meat and milk for large proportions of people in Egypt and worldwide. Brucellosis …
supplier of meat and milk for large proportions of people in Egypt and worldwide. Brucellosis …
Pathogenic single nucleotide polymorphisms on autophagy-related genes
I Tamargo-Gómez, ÁF Fernández, G Mariño - International Journal of …, 2020 - mdpi.com
In recent years, the study of single nucleotide polymorphisms (SNPs) has gained increasing
importance in biomedical research, as they can either be at the molecular origin of a …
importance in biomedical research, as they can either be at the molecular origin of a …
Genome-Wide Re-Sequencing Data Reveals the Population Structure and Selection Signatures of Tunchang Pigs in China
F Wang, Z Zha, Y He, J Li, Z Zhong, Q Xiao, Z Tan - Animals, 2023 - mdpi.com
Simple Summary The Tunchang pig has characteristics such as tolerance of coarse feed,
strong disease resistance, and delicious meat. In 2014, it was listed as one of the main …
strong disease resistance, and delicious meat. In 2014, it was listed as one of the main …