[HTML][HTML] Genetic aberrations in macroautophagy genes leading to diseases

N van Beek, DJ Klionsky, F Reggiori - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
The catabolic process of macroautophagy, through the rapid degradation of unwanted
cellular components, is involved in a multitude of cellular and organismal functions that are …

A current view of molecular dissection in autophagy machinery

MAA Al-Bari - Journal of physiology and biochemistry, 2020 - Springer
Macroautophagy (hereafter called autophagy) is a highly conserved lysosomal pathway for
catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential …

Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells

W Liu, M Chen, C Liu, L Wang, H Wei, R Zhang, Z Ren… - Autophagy, 2023 - Taylor & Francis
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian
defect in humans characterized by the premature depletion of ovarian follicles before the …

PI4K2A deficiency causes innate error in intracellular trafficking with developmental and epileptic‐dyskinetic encephalopathy

HS Dafsari, JG Pemberton, EA Ferrer… - Annals of Clinical …, 2022 - Wiley Online Library
Objective Intracellular signaling networks rely on proper membrane organization to control
an array of cellular processes such as metabolism, proliferation, apoptosis, and …

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

C Lanzillotta, I Zuliani, A Tramutola, E Barone… - Progress in …, 2021 - Elsevier
A major challenge in neurobiology is the identification of the mechanisms by which protein
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …

[HTML][HTML] Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation

J Gu, K Li, H Lin, Y Wang, Y Zhou, D Chen, X Gu… - Ecotoxicology and …, 2023 - Elsevier
Environmental and occupational exposure to cadmium (Cd) poses a serious threat to human
health. Recent studies indicate that Cd perturbs the immune system and increases the risk of …

CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome

S Pagnotta, A Tramutola, E Barone… - Free Radical Biology …, 2022 - Elsevier
The cells possess several mechanisms to counteract the over-production of reactive oxygen
species (ROS) and reactive nitrogen species (RNS), including enzymes such as superoxide …

New insights into the genetic predisposition of brucellosis and its effect on the gut and vaginal microbiota in goats

AM Sallam, I Abou-Souliman, H Reyer, K Wimmers… - Scientific Reports, 2023 - nature.com
Goats contribute significantly to the global food security and industry. They constitute a main
supplier of meat and milk for large proportions of people in Egypt and worldwide. Brucellosis …

Pathogenic single nucleotide polymorphisms on autophagy-related genes

I Tamargo-Gómez, ÁF Fernández, G Mariño - International Journal of …, 2020 - mdpi.com
In recent years, the study of single nucleotide polymorphisms (SNPs) has gained increasing
importance in biomedical research, as they can either be at the molecular origin of a …

Genome-Wide Re-Sequencing Data Reveals the Population Structure and Selection Signatures of Tunchang Pigs in China

F Wang, Z Zha, Y He, J Li, Z Zhong, Q Xiao, Z Tan - Animals, 2023 - mdpi.com
Simple Summary The Tunchang pig has characteristics such as tolerance of coarse feed,
strong disease resistance, and delicious meat. In 2014, it was listed as one of the main …