The functional capabilities of skeletal muscle are strongly correlated with its well-arranged
microstructure, consisting of parallelly aligned myotubes. In case of extensive muscle loss …

Skeletal muscles play important roles in critical body functions and their injury or disease
can lead to limitation of mobility and loss of independence. Current treatments result in …

Developing an injectable anisotropic scaffold with precisely topographic cues to induce 3D
cellular organization plays a critical role in volumetric muscle loss (VML) repair in vivo …

Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the
native regenerative properties of skeletal muscle and results in lifelong functional deficits …

Millions of Americans suffer from skeletal muscle injuries annually that can result in
volumetric muscle loss (VML), where extensive musculoskeletal damage and tissue loss …

Anisotropic microarchitectures arising from an aligned organization of threadlike
extracellular matrix (ECM) components or cells are ubiquitous in the human body, such as …

Soft tissue reconstructs require materials that form three-dimensional (3-D) structures
supportive to cell proliferation and regenerative processes. Polysaccharides, due to their …

Although skeletal muscle is highly regenerative following injury or disease, endogenous self‐
regeneration is severely impaired in conditions of volume traumatic muscle loss …

Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …

Volumetric muscle loss (VML), characterized by an irreversible loss of skeletal muscle due to
trauma or surgery, is accompanied by severe functional impairment and long-term disability …