The actin cytoskeleton plays key roles in every eukaryotic cell and is essential for cell
adhesion, migration, mechanosensing, and contractility in muscle and non-muscle tissues …

At the nexus of specialized cellular responses are localized enrichments of protein activity.
The localization of messenger RNA (mRNA) coupled with translational control often plays a …

Claudins are a family of transmembrane proteins expressed in epithelial tissues and are the
major components of tight junctions (TJs), which define barrier properties in epithelia and …

The integrity and functions of epithelial barriers depend on the formation of adherens
junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their …

Intestinal epithelial barrier is critical for the maintenance of normal gut homeostasis and
disruption of this barrier may trigger or exaggerate mucosal inflammation. The actin …

Cumulative evidence demonstrates that most RNAs exhibit specific subcellular distribution.
However, the mechanisms regulating this phenomenon and its functional consequences are …

Actin is one of the most abundant intracellular proteins, essential in every eukaryotic cell
type. Actin plays key roles in tissue morphogenesis, cell adhesion, muscle contraction, and …

The protein-coding regions of mRNAs have the information to make proteins and hence
have been at the center of attention for understanding altered protein functions in disease …

Cytoplasmic pressure, a function of actomyosin contractility and water flow, can regulate
cellular morphology and dynamics. In mesenchymal cells, cytoplasmic pressure powers cell …

Regulating adherens junction complex assembly/disassembly is critical to maintaining
epithelial homeostasis in healthy epithelial tissues. Consequently, adherens junction …