Objectives Malformations of cortical development (MCDs) are common causes of drug-
resistant epilepsy. The mechanisms underlying the associated epileptogenesis and …

We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …

Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large
intermittent electrophysiological events observed between seizures in patients with epilepsy …

Dysfunction of gamma-aminobutyric acid (GABA) ergic circuits is strongly associated with
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …

Background: Inhalational anesthetic-induced burst suppression (BS) is classically
considered a bilaterally synchronous rhythm. However, local asynchrony has been …

Burst suppression (BS) is an electroencephalogram (EEG) pattern in which signals
alternates between high-amplitude slow waves (burst waves) and nearly flat low-amplitude …

Interictal electroencephalogram (EEG) patterns, including high-frequency oscillations
(HFOs), interictal spikes (ISs), and slow wave activities (SWAs), are defined as specific …

Objective Focal epilepsy is thought to be a network disease, in which epileptiform activity
can spread noncontiguously through the brain via highly interconnected nodes, or hubs …

Accurate epileptogenic zone (EZ) or seizure onset zone (SOZ) localization is crucial for
epilepsy surgery optimization. Previous animal and human studies on epilepsy have …

We present a patient with pharmacoresistant non-lesional epilepsy who underwent non-
dominant orbitofrontal and temporal pole resective surgery. We review the post-operative …