New treatment development for psychiatric disorders depends critically upon the
development of physiological measures that can accurately translate between preclinical …

Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …

There is converging evidence that 40-Hz auditory steady-state responses (ASSRs) are
robustly impaired in schizophrenia and could constitute a potential biomarker for …

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world's
population. Social-cognitive impairments in SZ prevent positive social interactions and lead …

Background Thirty percent of patients with schizophrenia do not respond to non-clozapine
antipsychotics and are termed treatment-resistant schizophrenia (TRS). The 40-Hz auditory …

Introduction Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses
pulsed magnetic fields to affect the physiology of the brain and central nervous system …

The 40 Hz auditory steady-state response (ASSR), an oscillatory brain response to
periodically modulated auditory stimuli, is a promising, noninvasive physiological biomarker …

Electrophysiological oscillations in the brain have been shown to occur as multicycle events,
with onset and offset dependent on behavioral and cognitive state. To provide a baseline for …